22
32
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12352L |
Oxidopamine hydrobromide
6-Hydroxydopamine hydrobromide,6-羟基多巴胺氢溴酸盐,6-OHDA hydrobromide |
Mitophagy; Dopamine Receptor; Autophagy | Autophagy; GPCR/G Protein; Neuroscience |
Oxidopamine hydrobromide (6-OHDA hydrobromide) 是一种神经递质多巴胺拮抗剂,可选择性地破坏多巴胺能神经元,是一种广泛使用的神经毒素。 | |||
T12352 |
Oxidopamine hydrochloride
6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride,6-羟基多巴胺盐酸盐 |
Mitophagy; Dopamine Receptor; Autophagy | Autophagy; GPCR/G Protein; Neuroscience |
Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) 是一种神经递质多巴胺拮抗剂,可选择性地破坏多巴胺能神经元,是一种广泛使用的神经毒素。 | |||
T12384 |
PD 90780
|
Others | Others |
PD 90780 是神经生长因子 (NGF) 的非肽拮抗剂。PD 90780 与 NGF 相互作用阻止与 p75NTR 结合。PD 90780 抑制 NGF-p75NTR 相互作用,在 PC12 和 PC12nnr5 细胞中的 IC50 值分别为 23.1 和 1.8 µM | |||
T21919 |
UCF 101
|
Apoptosis | Apoptosis |
UCF 101 是竞争性的促凋亡蛋白酶Omi/HtrA2选择性抑制剂。它对 MI/R 损伤具有明显的心脏保护作用,还具有一定的神经保护作用。它在 543 nm 处具有天然的红色荧光,可用于监视其进入哺乳动物细胞的能力。 | |||
T15602 |
ITX3
|
Others; Rho | Cell Cycle/Checkpoint; Others |
ITX3 是特异的、无毒的、有活性的、具有选择性的TrioN RhoGEF 抑制剂,IC50 值为 76 μM。 ITX3具有抗癌作用,能抑制trion 介导的GTP 在RhoG 和Rac1上的交换,抑制ngf 介导的PC12细胞神经突的生长和trion 诱导的REF52成纤维细胞结构的形成。 | |||
T29543 |
ACAF4
ACAF-4,ACAF 4 |
||
ACAF4 is a neurotrophic agent which significantly increases survival in PC12 neuronal cells and enhances the effect of nerve growth factor (NGF). ACAF4 induces neurite outgrowth, and modulates ERK1/2 and AKT signaling pathways. | |||
T27526 |
Halenaquinone
|
||
Halenaquinone is a phosphatidylinositol 3-kinase inhibitor. Halenaquinone specifically inhibits the secondary DNA binding of RAD51. Halenaquinone inhibits RANKL-induced osteoclastogenesis. Halenaquinone induces apoptosis in PC12 cells. | |||
T71903 |
Meclocycline
|
||
Meclocycline is a tetracycline antibiotic with broad antimicrobial activity. Meclocycline inhibits lactate dehydrogenase (LDH) release and cell toxicity induced by expression of htt-N63-148Q, a mutant form of the huntingtin gene, without altering htt-N63-148Q protein levels in PC12 cells. | |||
TP1490 |
Proadrenomedullin (1-20), human
|
||
Endogenous peptide agonist of Mas related GPR X2 (MRGPRX2, EC50 = 251 nM). Also a noncompetitive nicotinic cholinergic antagonist. Inhibits nicotine-stimulated catecholamine secretion from PC12 cells in vitro, and from sympathetic nerve endings and adrena | |||
T79273 |
NMDA receptor antagonist 6
|
iGluR | Membrane transporter/Ion channel; Neuroscience |
NMDA receptor antagonist6 (compound 13b) 为针对甘氨酸结合位点的NMDA 受体拮抗剂,其展现出对PC12 细胞的神经保护功能,能够抵御NMDA引起的细胞损伤及细胞凋亡。 | |||
T36453 |
1-Myristoyl-2-hydroxy-sn-glycero-3-PE
|
||
1-Myristoyl-2-hydroxy-sn-glycero-3-PE is a naturally occurring lysophospholipid. It induces transient increases in intracellular calcium in PC12 cells. Serum levels of 1-myristoyl-2-hydroxy-sn-glycero-3-PE are elevated in patients with malignant breast cancer compared to healthy controls. | |||
T61522 | Nrf2/HO-1 activator 2 | ||
Nrf2/HO-1 activator 2 (compound 13m), a difluoro-substituted derivative, is a highly potent activator of Nrf2/HO-1. It exhibits substantial neuroprotective and antioxidant properties by activating the Nrf2/HO-1 pathway through phosphorylation of ERK1/2, JNK, or Akt in PC12 cells. This compound finds utility in the investigation of Parkinson's disease (PD) [1]. | |||
T17282 |
Zaldaride maleate
CGS-9343B,KW 5617 |
Others | Others |
Zaldaride maleate inhibits CaM (calmodulin)-stimulated cAMP phosphodiesterase activity (IC50: 3.3 nM). Zaldaride maleate is an effective and selective inhibitor of calmodulin. Zaldaride maleate prevents estrogen-induced transcription activation by ER, re | |||
T38279 |
C2-8
C2-8 |
||
C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s = 25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively). It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isolated from R6/2 transgenic mice and reduces neurodegeneration in a dose-dependent manner in a Drosophila model of Huntington's disease. C2-8 (100 and 200 mg/kg) reduces huntingtin aggregate size, reduces neuronal atrophy, and improves motor performance in a rotarod test in the R6/2... | |||
T80418 |
TAT-NEP1-40
|
Apoptosis | Apoptosis |
TAT-NEP1-40是一种能够穿透血脑屏障的多肽。它能够保护PC12细胞不受缺氧和葡萄糖剥夺(OGD)所致的损伤,同时促进神经突的生长。此外,TAT-NEP1-40通过阻断缺血性脑损伤中的细胞凋亡,对缺血后的神经功能恢复具有积极作用。该化合物适用于中枢神经系统损伤,特别是中风后的轴突再生与功能恢复方面的研究。 | |||
TP2038 |
Decanoyl-RVKR-CMK
|
||
Subtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion of the neuronal polypeptide VGF in | |||
T80420 |
TAT-NEP1-40 acetate
|
Apoptosis | Apoptosis |
TAT-NEP1-40 acetate 是促进脑卒中后轴突再生和功能恢复的候选分子。该化合物能够抵御PC12细胞的氧和葡萄糖剥夺(OGD)损伤,并促进神经突生长。它通过抑制神经元凋亡(apoptosis)作用,保护大脑免受缺血再灌注伤害,并能有效传递至大鼠的脑内。 | |||
T80503 |
Proadrenomedullin (N-20) (bovine, porcine)
ProADM N20(bovine, porcine),PAMP-20(bovine, porcine) |
||
Proadrenomedullin (N-20) (bovine, porcine) 是一种来源于嗜铬细胞的、具有降压及抑制 catecholamine release 的非竞争性肽类。该化合物能显著抑制 PC12 嗜铬细胞瘤细胞的 catecholamine 分泌,显示出 350 nM 的 IC50 值。此外,Proadrenomedullin (N-20) (bovine, porcine) 作为 EC50 约为 270 nM 的阻断剂,能够有效抵抗烟碱能激动剂引起的 catecholamine release 脱敏现象和烟碱相关的信号通道 (22Na+摄取)。 | |||
T80419 |
TAT-NEP1-40 TFA
|
Apoptosis | Apoptosis |
TAT-NEP1-40 TFA 是一种能够穿透血脑屏障的多肽。它能够保护 PC12 细胞抵御缺氧和葡萄糖剥夺 (OGD) 的损害,并促进神经突的生长。此外,TAT-NEP1-40 TFA 可通过减少缺血性脑损伤中的细胞凋亡,以改善神经系统功能。该化合物在中枢神经系统损伤,包括中风后轴突再生及功能恢复的研究中具有潜在应用价值。 | |||
T37370 |
Amyloid-β (25-35) Peptide (human) (trifluoroacetate salt)
|
||
Amyloid-β (25-35) (Aβ (25-35)) is an 11-residue fragment of the Aβ protein that retains the physical and biological characteristics of the full length peptide. It forms fibrils that react to thioflavin T and Congo red and are organized in a cross-β arrangement of β-strands similar to Aβ (1-40) and Aβ (1-42) fibrils. Aggregated Aβ (25-35) decreases the viability of rat adrenal PC12 cells. It also decreases the viability of primary rat cortical neurons at concentrations ranging from 1 nM to 30 μM.... | |||
T36903 |
Rasagiline-13C3 (mesylate)
Rasagiline-13C3 (mesylate) |
||
Rasagiline-13C3is intended for use as an internal standard for the quantification of rasagiline by GC- or LC-MS. Rasagiline is an inhibitor of monoamine oxidase B (MAO-B; IC50= 4.43 nM for the rat brain enzyme).1It is selective for MAO-B over MAO-A (IC50= 412 nM for the rat brain enzyme). It inhibits serum and NGF withdrawal-induced apoptosis of PC12 cells when used at concentrations ranging from 0.01 to 100 μM.2Rasagiline inhibits rat brain MAO-Bin vivo(ED50= 0.1 mg/kg).1It reduces cerebral ede... | |||
T12738 |
Rivanicline hemioxalate
RJR-2403 hemioxalate,(E)-Metanicotine hemioxalate |
Others | Others |
Rivanicline hemioxalate (RJR-2403 hemioxalate; (E)-Metanicotine hemioxalate) 是一种神经元烟碱受体 (neuronal nicotinic receptor) 激动剂,对 α4β2 亚型有高度选择性(Ki= 26 nM),比对于 α7 受体的选择性高1000倍(Ki=3.6 μM)。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN6924 |
Anhydrosafflor yellow B
(2S,3S)-6,7-dihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-3-{2,3,4-trihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-oxo-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]cyclohexa-1,4-dien-1,脱水红花黄色素B,AHSYB |
Others | Others |
Anhydrosafflor yellow B ((2S,3S)-6,7-dihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-3-{2,3,4-trihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-oxo-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]cyclohexa-1,4-dien-1) 是从红花中分离出来的,可抑制 ADP 诱导的血小板聚集,在体外表现出显着的抗氧化作用,并对 H2O2 诱导的细胞毒性具有一定的活性。 | |||
T2S0531 |
Pinoresinol dimethyl ether
(+)-Eudesmin,松脂素二甲醚 |
Others; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; Others |
Pinoresinol dimethyl ether 是一种非酚性呋喃木质素,从 Magnolia kobus 茎皮中分离得到,具有神经活性。它可刺激上游 MAPK、PKC 和 PKA 通路,诱导 PC12 细胞神经突起生长。 | |||
TN6982 |
Diethyl phthalate
邻苯二甲酸二乙酯,1,2-diethyl benzene-1,2-dicarboxylate |
Apoptosis | Apoptosis |
Diethyl phthalate (1,2-diethyl benzene-1,2-dicarboxylate) 是一种内分泌干扰物,影响 PC12 细胞凋亡系统。Diethyl phthalate 广泛用于许多塑料和个人护理产品。 | |||
T5S2195 |
Sibiricose A5
西伯利亚远志糖A5 |
Dehydrogenase | Metabolism |
Sibiricose A5 是一种寡糖酯,分离自Polygalae Radix,具有抗氧化作用。 | |||
TN7108 |
Urolithin C
|
Apoptosis; Calcium Channel; Reactive Oxygen Species; IGF-1R; Endogenous Metabolite | Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB; Tyrosine Kinase/Adaptors |
Urolithin C 属于多酚类,是鞣花酸的肠道微生物代谢产物,具有胰岛素分泌的葡萄糖依赖性激活活性。Urolithin C 是 L 型 Ca2+通道开放剂,可增强 Ca2+的流入。它通过线粒体介导的途径诱导细胞凋亡,并刺激活性氧的形成。 | |||
T3836 |
Eudesmin
|
MAPK; S6 Kinase | MAPK; PI3K/Akt/mTOR signaling |
Eudesmin 通过抑制S6K1信号通路来干扰成脂分化,具有抗肿瘤、抗炎和抗菌活性。 | |||
TN2082 |
Pinostrobin
|
Beta Amyloid; IL Receptor; Serine/threonin kinase; TNF | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation; Metabolism; Neuroscience |
Pinostrobin 是一种 PCSK9抑制剂,可抑制 PCSK9 的催化活性。它是能够在多种植物中发现的黄酮类化合物,并具有抗氧化,抗炎,抗癌和神经保护作用。它是有前景的胆固醇调节和脂质管理剂。 | |||
T2854 |
Phillyrin
Forsythin,连翘苷 |
P450; Influenza Virus; AMPK | Chromatin/Epigenetic; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling |
Phillyrin (Forsythin) 是从连翘中分离出来的一种天然产物,具有抗甲型流感病毒的活性,以及抗菌和消炎作用。 | |||
T2823 |
Crocin
西红花苷,藏红花,Gardenia Yellow,Alpha-Crocin,藏红花素 |
Others | Others |
Crocin (Gardenia Yellow) 是从Crocus sativus 柱头中分离出的主要成分,是一种营养保健品,具有抗炎,抗癌,抗抑郁和抗惊厥等强大的药理作用。 | |||
T2S0843 |
Negletein
黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether |
IL Receptor; TNF; NOS; Interleukin | Apoptosis; Immunology/Inflammation |
Negletein (7-O-Methylbaicalein) 一种神经保护剂,可增强神经生长因子的作用并诱导 PC12 细胞中的神经突生长。它通过抑制TNF-α和IL-1β表现出抗炎活性,其 IC50值分别为 16.4 和 10.8 μM。它还具有抗菌、抗缺氧和抗阿尔茨海默病活性。 | |||
T37280 |
PE(18:1(9Z)/0:0)
|
Endogenous Metabolite | Metabolism |
PE(18:1(9Z)/0:0) 是一种天然存在的溶血磷脂,是缩醛磷脂溶血磷脂酰乙醇胺的类似物。 PE(18:1(9Z)/0:0) 以浓度依赖性方式诱导 PC12 大鼠神经元细胞中细胞内钙的瞬时增加。 PE(18:1(9Z)/0:0) 增加 IL-4 和 IL-2 的产生,但不增加 IFN-γ 的产生。 在小鼠血清中,PE(18:1(9Z)/0:0)(1 μg/动物)诱导 T 辅助细胞 2 反应。 在寒冷暴露三天后,小鼠肩胛间棕色脂肪组织中的 PE(18:1(9Z)/0:0) 水平增加。 | |||
T4956 |
Tetrahydroxystilbene-2-O-β-D-glucoside
tetrahydroxyl diphenylethylene-2-o-gluco,何首乌苷,EH-201 |
Others | Others |
Tetrahydroxystilbene-2-O-β-D-glucoside (EH-201) 是一种低分子量的促红细胞生成素诱导剂。 | |||
T3826 |
Polygalasaponin F
异牡荆苷,瓜子金皂苷己 |
NF-κB; TLR; Akt; PI3K | Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR signaling |
Polygalasaponin F 是从瓜子金中提取的齐墩果烷型三萜皂苷,可通过调节TLR4-PI3K/AKT-NF-kB 信号通路减少神经炎症细胞因子的分泌,能降低炎性细胞因子肿瘤坏死因子 α 的释放。 | |||
TN4127 |
Gentiside J
|
Others | Others |
Gentiside J is a potent inducer of neurite outgrowth on PC12 cells. | |||
TN3618 |
Cedrin
|
Beta Amyloid; BCL; Caspase | Apoptosis; Neuroscience; Proteases/Proteasome |
Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative stress, improvement of mitochondrial dysfunction and suppression of apoptosis. | |||
TN4126 |
Gentiside B
|
Others | Others |
Gentiside B is a potent inducer of neurite outgrowth on PC12 cells, it shows a significant neuritogenic activity at 30 microM against PC12 cells that is comparable to that seen for the best nerve growth factor (NGF) concentration of 40 ng/mL. | |||
T29462 |
5-OH-HxMF
|
||
5-OH-HxMF is an inducer of neurite growth in PC12 cells through the camp / PKA / CREB pathway. | |||
T82444 |
Erinacine U
|
||
Erinacine U, a cyanhydrin diterpene isolated from Hericium erinaceus, exhibits neurotrophic activity and notably promotes neurite outgrowth in PC12 cells. | |||
T81213 | Sarbronine M | ||
Scabronine M为新型NGF诱导的PC12细胞突起生长抑制剂。 | |||
TMA2419 |
Catalponol
|
cAMP | GPCR/G Protein |
Catalponol can enhance dopamine biosynthesis by inducing TH activity and protect against L-DOPA-induced cytotoxicity in PC12 cells, which was mediated by the increased levels of cyclic AMP. | |||
TN1726 |
Heishuixiecaoline A
|
Others | Others |
Heishuixiecaoline A protects against neurotoxicity in PC12 cells. | |||
T83268 | 6-Epiagarotetrol | ||
6-Epiagarotetrol,一种从Aquilaria sinensis中提取的神经保护剂,对corticosterone诱导的PC12细胞损伤表现出保护效应。 | |||
TN4651 | Neuchromenin | Others | Others |
(-)-Neuchromenin is an inducer of neurite outgrowth of PC12 cells at concentration of 2.5-10 ug/ml. | |||
T37957 |
Setosusin
|
||
Setosusin is a meroterpenoid fungal metabolite originally isolated from C. setosus. It reduces neurotoxicity induced by amyloid-β (Aβ) aggregates in PC12 cells (EC50 = 112.6 μM). In vivo, setosusin (30 mg/kg) induces tremors in mice. | |||
TN4935 |
Salvianolic acid Y
|
Others | Others |
Salvianolic acid Y 从丹参 Salvia officinalis 中分离出来,是 PC12 细胞免受过氧化氢诱导的丹参损伤的保护剂。 | |||
TN2844 |
(2R,3S)-Dihydrodehydroconiferyl alcohol
|
MAPK; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK |
(2R,3S)-Dihydrodehydroconiferyl alcohol can induce neurite outgrowth and enhance NGF-induced neurite outgrowth from PC12 cells by amplifying up-stream steps such as MAPK and PKC. | |||
T19882 |
Bryonolic acid
UNII-J7YR6A878I,20-epi-Bryonolic acid |
Apoptosis; Antioxidant; Calcium Channel | Apoptosis; Membrane transporter/Ion channel; Metabolism; oxidation-reduction |
Bryonolic acid (20-epi-Bryonolic acid) 是一种从 Sandoricum indicum 提取的三萜类化合物,具有免疫调节、抗炎,抗氧化和抗癌等活性,通过抑制Ca2+内流和调节Ca2+-CaMKII-CREB信号通路中的基因表达来避免PC12细胞免受NMDA诱导的细胞凋亡反应。 | |||
TN6469 | Biatractylolide | ||
Biatractylolide has a neuroprotective effect on glutamate-induced injury in PC12 and SH-SY5Y cells through a mechanism of the PI3K-Akt-GSK3β-dependent pathways. The molecular mechanisms of inhibitory activities of biatractylolide on AChE are not only thro | |||
TMA0984 |
Cerevisterol
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Cerevisterol 是一种细胞毒性类固醇,提取于Agaricus blazei 子实体,对 DNA 聚合酶 α 的活性具有抑制作用。 | |||
TN6515 |
Selaginellin
|
||
Selaginellin has a neuroprotective effect against L-glutamate-induced neurotoxicity through mechanisms related to anti-oxidation and anti-apoptosis via scavenging reactive oxygen species and up-regulating the expression of klotho gene. Selaginellin shows | |||
TN3607 | Catalpalactone | cAMP | GPCR/G Protein |
Catalpalactone exhibits high antitermitic, and cytotoxic activities, it exhibits potent inhibitory effects on lipopolysaccharide-induced NO synthesis in RAW 264.7 cells , with IC50 values of 9.80 microM. Catalpalactone can inhibit dopamine biosynthesis by | |||
TN2626 | 14-Norpseurotin A | Antifection | Microbiology/Virology |
14-Norpseurotin A shows good antileishmanial and moderate anticancer activities. It also displays significant antimicrobial activities against Escherichia coli, Bacillus subtilis, and Micrococcus lysoleikticus with MICs of 3.74, 14.97, and 7.49 microM , r |